The LIM domain: regulation by association
نویسندگان
چکیده
منابع مشابه
The LIM domain: regulation by association
The LIM domain is a zinc finger structure that is present in several types of proteins, including homeodomain transcription factors, kinases and proteins that consist of several LIM domains. Proteins containing LIM domains have been discovered to play important roles in a variety of fundamental biological processes including cytoskeleton organization, cell lineage specification and organ develo...
متن کاملRegulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134.
LDB1 (LIM-domain-binding 1) is a cofactor that participates in formation of transcriptional regulatory complexes involving transcription factors containing LIM domains as well as other factors. The amount of LDB1 protein in cells has previously been shown to be modulated by RNF12 (RING finger protein 12). RNF12 is an E3 ubiquitin ligase that can target LDB1 for poly-ubiquitination and degradati...
متن کاملNegative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein.
LIM domain only 4 (LMO4), a member of the LIM-only family of transcriptional coregulatory proteins, consists of two LIM protein-protein interaction domains that enable it to function as a linker protein in multiprotein complexes. Here, we have identified estrogen receptor alpha (ERalpha) and its corepressor, metastasis tumor antigen 1 (MTA1), as two novel binding partners of LMO4. Interestingly...
متن کاملNegative Regulation of Estrogen Receptor A Transactivation Functions by LIM Domain Only 4 Protein
LIM domain only 4 (LMO4), a member of the LIM-only family of transcriptional coregulatory proteins, consists of two LIM protein-protein interaction domains that enable it to function as a linker protein in multiprotein complexes. Here, we have identified estrogen receptor A (ERA) and its corepressor, metastasis tumor antigen 1 (MTA1), as two novel binding partners of LMO4. Interestingly, LMO4 e...
متن کاملSingle-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins.
The LIM domain-binding protein Ldb1 is an essential cofactor of LIM-homeodomain (LIM-HD) and LIM-only (LMO) proteins in development. The stoichiometry of Ldb1, LIM-HD, and LMO proteins is tightly controlled in the cell and is likely a critical determinant of their biological actions. Single-stranded DNA-binding proteins (SSBPs) were recently shown to interact with Ldb1 and are also important in...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2000
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(99)00314-7